Which term describes the pathologic endocrine and immune responses that promote metabolic diseases such as diabetes mellitus and hypertension?

The term "sick fat disease" accurately reflects the concept of adipose tissue dysfunction that contributes to metabolic diseases like diabetes mellitus and hypertension. This term emphasizes how excessive fat accumulation leads to a state of chronic inflammation, altered hormone secretion, and adverse metabolic changes.

In the context of obesity, adipose tissue is not merely a passive storage depot for excess calories; it actively engages in endocrine and immune activities that impact overall health. The pathological state of "sick fat" indicates that adipose tissue has transitioned from a healthy, metabolically neutral state to one that exacerbates disease processes, such as insulin resistance, systemic inflammation, and changes in lipid metabolism.

By recognizing "sick fat disease" as a key contributor to metabolic conditions, healthcare providers can better understand the role of obesity in these diseases and emphasize the importance of addressing abdominal obesity and its associated inflammatory mechanisms in treatment strategies.