Which of the following is a potential risk factor for lactic acidosis associated with Metformin use?

The correct choice highlights that age greater than 65 years is a potential risk factor for lactic acidosis associated with Metformin use. In older individuals, there are several physiological changes that can alter drug metabolism and clearance. The renal function often declines with age, which is critical because Metformin is primarily excreted by the kidneys. When kidney function is impaired, Metformin and its metabolite can accumulate, increasing the risk of lactic acidosis, especially if combined with other factors like dehydration or any condition that might further compromise renal function.

Increased age commonly correlates with a higher prevalence of comorbidities that can complicate treatment and increase the likelihood of adverse effects. Therefore, when prescribing Metformin to older patients, healthcare providers need to carefully monitor renal function and consider the risk of acidosis, particularly if there are other complicating factors.

The other options, while they may be relevant in the context of diabetes management and overall health, do not specifically increase the risk of lactic acidosis associated with Metformin in the same manner as advancing age does. For example, significant weight loss may actually help improve insulin sensitivity and metabolic control, while diabetes itself is the condition that Metformin is prescribed to manage, and insulin resistance is a