Which of the following is an adverse reaction associated with setmelanotide?

Setmelanotide is a melanocortin-4 receptor agonist used for the treatment of obesity associated with specific genetic conditions. One important aspect to understand regarding this medication is its potential psychological effects, particularly concerning mood disorders.

Worsening depression or suicidal ideation has been documented as an adverse reaction linked to the use of setmelanotide. Melanocortin receptors, upon which this medication acts, have roles beyond metabolic regulation; they can also influence mood and emotional states. Therefore, patients on setmelanotide may experience changes in mental health, necessitating careful monitoring for any signs of depressive symptoms or thoughts of suicide.

The other potential side effects, like hypotension, nausea, and even weight gain, are not primarily highlighted in the clinical literature regarding setmelanotide. While nausea may occur with many medications, it does not specifically characterize setmelanotide's side effect profile. Similarly, hypotension is not commonly reported in this context, and weight gain is not an intended effect of the drug; instead, it aims to promote weight loss.

Thus, the recognition of worsening depression or suicidal ideation as a serious and significant adverse effect emphasizes the need for thorough patient evaluation and ongoing mental health monitoring when prescribing setmel