Which of the following GI hormones is known to INCREASE after weight loss?

Gastric inhibitory peptide (GIP) is a hormone produced by the K-cells in the small intestine that plays a significant role in glucose metabolism and insulin secretion. After weight loss, several hormonal changes occur in the body as a response to changes in energy balance and body composition.

Increased levels of GIP after weight loss can be attributed to its role in enhancing insulin sensitivity and promoting glucose homeostasis, which may become more pronounced as body weight decreases. This hormonal adaptation may reflect an improved metabolic state following weight loss, as GIP aids in regulating the feedback mechanisms in energy intake and expenditure.

In contrast, hormones such as leptin, which typically decreases with weight loss, primarily signal satiety to the brain. Cholecystokinin (CCK) is involved in promoting feelings of fullness after eating but does not demonstrate a clear increase in levels post-weight loss. Peptide YY (PYY), which also reduces appetite and is secreted by the intestines, usually decreases after weight loss. Thus, the increase in GIP after weight loss highlights its critical role in the metabolic adaptations that occur as body weight changes, making it essential for understanding the physiological responses in individuals managing their weight.