Which of the following anti-obesity agents acts through GLP-1?

The correct choice is that GLP-1 analogs act through the glucagon-like peptide-1 pathway, which is crucial in regulating appetite and insulin secretion. These agents mimic the action of the natural hormone GLP-1, which promotes satiety and reduces food intake. In addition, they slow gastric emptying and help regulate blood sugar levels, making them valuable for individuals struggling with obesity and associated metabolic disorders.

Orlistat, on the other hand, works through a different mechanism by inhibiting the absorption of dietary fats in the intestine. Phentermine is a stimulant that suppresses appetite but does not act through the GLP-1 pathway.

Thus, while Orlistat and Phentermine have their respective roles in weight management, they do not interact with GLP-1 mechanisms. The actions of GLP-1 analogs are significant in obesity treatment, primarily as they provide both appetite suppression and potential metabolic benefits, confirming their prominence in modern anti-obesity pharmacotherapy.