Which medication is the only FDA-approved treatment for Binge Eating Disorder?

The only FDA-approved medication specifically for the treatment of Binge Eating Disorder (BED) is Lisdexamfetamine dimesylate. This medication is a central nervous system stimulant that has been shown to reduce binge-eating episodes and improve associated symptoms in individuals diagnosed with BED. Its mechanism involves enhancing the release of certain neurotransmitters in the brain, which can help regulate appetite and mood.

Other medications, such as fluoxetine and sertraline, while used off-label for BED, are primarily approved for the treatment of depression and other anxiety-related disorders. They have not received formal approval specifically for BED despite showing potential benefits in some patients. Topiramate, although also used off-label for weight loss and other indications, is not specifically indicated for BED, as it does not have FDA approval for this disorder. Thus, Lisdexamfetamine dimesylate stands out as the treatment with established efficacy and approval for BED, making it the correct choice among the options provided.