Which hormone is commonly associated with satiety and is expected to decrease after weight loss?

The hormone associated with satiety that is expected to decrease after weight loss is PYY, also known as peptide YY. PYY is released by the gastrointestinal tract in response to food intake, particularly from the ileum and colon, and it acts on the brain to promote feelings of fullness after meals.

After weight loss, the body may adapt by changing the levels of various hormones involved in hunger and satiety. PYY levels typically decrease as a result of weight loss, which can affect appetite regulation by reducing the sensation of fullness. This hormonal adjustment can make it challenging for individuals who have lost weight to maintain their new weight, as decreased PYY may lead to increased hunger and food intake.

In contrast, hormones like CCK, which also plays a role in satiety, may not show the same patterns post-weight loss. Ghrelin, known as the "hunger hormone," actually increases after weight loss, which drives appetite and can complicate weight management. Insulin, while involved in metabolic processes and hunger signaling, does not directly correlate to the satiety mechanisms in the same manner as PYY does when specifically considering the effects of weight loss.

Thus, the unique interplay between PYY and weight fluctuation highlights why its levels are