Which GI hormone DECREASES after weight loss?

Leptin is a hormone that plays a crucial role in regulating energy balance and body weight. It is primarily secreted by adipose (fat) tissue, and its levels are directly related to the amount of body fat. When an individual loses weight, the total amount of adipose tissue decreases, which subsequently leads to a reduction in leptin levels. This decrease can have significant implications for appetite regulation and energy expenditure.

In conjunction with weight loss, lower leptin levels can signal to the brain that energy stores are reduced, which may increase hunger and decrease energy expenditure, making it more challenging for individuals to maintain weight loss. This physiological response is an adaptation to help defend against weight loss and maintain body weight.

Understanding leptin's role provides insight into the complex regulation of hunger and metabolism following weight loss.