Which class of anti-diabetes medications is known to promote weight gain?

Sulfonylureas are a class of anti-diabetes medications that can lead to weight gain as a notable side effect. They work by stimulating insulin release from the pancreas, which can increase appetite and, consequently, caloric intake. This mechanism, while effective in lowering blood glucose levels, frequently results in weight gain among individuals using these medications.

In contrast, other classes of medications, such as metformin and GLP-1 agonists, are typically associated with weight loss or weight neutrality. Metformin often promotes modest weight loss, partly due to its effects on reducing appetite and improving insulin sensitivity. GLP-1 agonists can help with weight loss by promoting satiety and reducing food intake. DPP-4 inhibitors are generally considered weight neutral, meaning they do not significantly affect body weight.

Understanding the weight-related effects of these medications is crucial for developing comprehensive diabetes treatment plans, especially in individuals who are also managing obesity.