Where is GLP secreted in the human body?

Glucagon-like peptide (GLP) is primarily secreted by L cells located in the ileum and colon. These L cells play a crucial role in the regulation of glucose metabolism, insulin secretion, and overall appetite control. Upon the ingestion of food, particularly carbohydrates, L cells release GLP-1, which stimulates insulin secretion from the pancreas and inhibits glucagon release. Additionally, GLP-1 helps slow gastric emptying and significantly affects satiety.

The secretion of GLP by these specific intestinal cells reflects their adaptation to nutrient intake and their involvement in the enteroendocrine system, which plays an essential role in gastrointestinal processing and metabolic regulation. This physiological process highlights the importance of L cells in managing postprandial blood glucose levels and influencing weight management strategies.

In contrast, secretions from the liver, pancreas, or stomach are associated with different hormones and functions, such as glucose production or hormone secretion related to digestion, but they do not produce GLP.