What is the role of PYY in relation to gastric and intestinal emptying?

PYY, or peptide YY, is a hormone produced by the L cells in the intestine in response to food intake. Its primary role is to help regulate appetite and digestion. When discussing gastric and intestinal emptying, PYY acts to delay both of these processes.

The hormone's secretion is stimulated after eating, particularly in response to nutrient intake. When PYY is released into the bloodstream, it signals the body to slow down gastric emptying, meaning that the stomach empties its contents into the small intestine more slowly. This delay provides several benefits, including a prolonged sensation of fullness and a more gradual release of nutrients into the bloodstream, which contributes to better blood sugar control.

PYY also plays a part in inhibiting intestinal motility, which further contributes to its role in slowing down the emptying of material from the intestines. This mechanism not only supports satiety but also enhances nutrient absorption, as it allows more time for the body to absorb the nutrients released from food.

In summary, PYY's role in delaying gastric and intestinal emptying is essential for regulating appetite, promoting satiety after meals, and potentially improving nutrient absorption.