What is the mechanism of action of oxyntomodulin?

Oxyntomodulin is a peptide hormone that plays a significant role in the regulation of appetite and energy balance. It is produced by the L-cells in the intestines in response to food intake. The primary mechanism of action for oxyntomodulin is that it acts on the central nervous system and peripheral tissues to decrease appetite while simultaneously increasing energy expenditure.

The correct understanding is that oxyntomodulin can bind to the receptors for glucagon and GLP-1 (glucagon-like peptide-1), resulting in reduced feelings of hunger and a greater feeling of fullness after eating. In addition to its suppressive effect on appetite, oxyntomodulin has been shown to elevate energy expenditure, thereby contributing to weight loss and metabolic regulation. This dual action highlights its potential therapeutic role in obesity management.

By enhancing energy expenditure, oxyntomodulin provides a mechanism that can counteract weight gain, making the correct choice align with its physiological roles in promoting satiety and influencing energy balance in the body.