What is a useful add-on therapy for managing psychotropic-induced weight gain?

Metformin is recognized as a beneficial add-on therapy for managing weight gain induced by psychotropic medications. This medication, typically used in the treatment of type 2 diabetes, has also been shown to have weight-regulating properties. It works by improving insulin sensitivity and enhancing the metabolism of glucose, which can contribute to weight loss or weight stabilization in patients who experience excessive weight gain as a side effect of certain antipsychotic or antidepressant medications.

In clinical practice, metformin has demonstrated efficacy in helping individuals manage weight gain linked to psychotropic drugs, making it a preferred option among practitioners. The mechanism through which metformin works—such as reducing appetite and lowering the amount of glucose produced by the liver—can counteract the weight-promoting effects of psychotropic treatments.

Though other medications may have their own potential benefits, metformin's established role in weight management, especially for individuals undergoing treatment with agents that contribute to weight gain, underscores its importance as an effective add-on therapy in this context.