Oxyntomodulin is produced in which location?

Oxyntomodulin is primarily produced in the distal small bowel and colon, specifically by the L-cells in these regions. This incretin hormone is released in response to nutrient intake, particularly in the presence of carbohydrates and fats. It plays a role in promoting satiety, reducing appetite, and enhancing insulin secretion when glucose levels rise.

While some hormones related to gastrointestinal function are produced in the stomach or pyloric region, oxyntomodulin's specific production location is limited to the distal parts of the small intestine and the colon. This distinction is particularly important as it relates to the gut-brain axis in the regulation of appetite and energy homeostasis. Understanding the exact source of oxyntomodulin helps in grasping its role in metabolic regulation and the treatment of obesity and related disorders.