Orlistat is known to increase the risk of which type of kidney stones?

Orlistat is a weight-loss medication that works by inhibiting the absorption of dietary fats in the gastrointestinal tract. While it can be effective in promoting weight loss, one of the notable side effects associated with its use is the potential increase in the risk of calcium oxalate kidney stones.

Calcium oxalate stones are the most common type of kidney stones, formed from calcium and oxalate, a substance found in various foods. Orlistat alters the absorption of fats, which can lead to changes in the way the body metabolizes calcium and oxalate. When the absorption of fat is reduced, it may create an imbalance in urinary composition, leading to higher concentrations of calcium and oxalate, thus increasing the likelihood of stone formation.

The risk of developing calcium oxalate stones is particularly relevant for individuals using Orlistat, as dietary fat reduction could increase the relative excretion of oxalate in the urine, promoting the formation of these types of kidney stones. This mechanistic link between Orlistat usage and calcium oxalate stones is well-documented and serves as a crucial consideration for individuals on this medication, especially those with a history of kidney stones.