Is pancreatic polypeptide considered anorexigenic or orexigenic?

Pancreatic polypeptide is considered anorexigenic, meaning it suppresses appetite. This hormone is produced in the pancreas and plays a role in regulating food intake and energy homeostasis. Studies have shown that increased levels of pancreatic polypeptide are associated with reduced food consumption and promotion of satiety.

When released, it acts on receptor sites in the hypothalamus and other areas of the brain to signal fullness and decrease hunger signals. This reinforces the idea that pancreatic polypeptide contributes to the regulation of energy balance by promoting feelings of satiety after meals, making it a key player in understanding appetite control mechanisms.

In contrast, substances that are orexigenic promote appetite and food intake, which does not align with the function of pancreatic polypeptide. Other hormones and signals in the body, such as ghrelin and neuropeptide Y, are recognized for their orexigenic properties while pancreatic polypeptide embodies the opposite function.