In which demographic is Borgeson-Forssman-Lehmann syndrome predominantly observed?

Borgeson-Forssman-Lehmann syndrome is a rare genetic disorder that predominantly affects males. This condition is characterized by various developmental and growth abnormalities, along with distinctive facial features. The gender predisposition is attributed to its X-linked inheritance pattern, which primarily expresses in males who carry the mutation on their single X chromosome. Females, having two X chromosomes, are often either unaffected or may present with milder symptoms due to the presence of a potentially normal gene on their other X chromosome. Therefore, the male predominance in this syndrome is directly related to its genetic inheritance, making it a key factor in understanding the demographic distribution of the condition.