How does testosterone replacement improve metabolic parameters?

Testosterone replacement therapy has been shown to improve metabolic parameters significantly, particularly through its role in enhancing glucose regulation. When testosterone levels are restored to normal, it can lead to improved insulin sensitivity and better glycemic control, reducing the risk of developing type 2 diabetes. This effect can be attributed to testosterone's influence on various biochemical pathways related to glucose metabolism.

In addition to glucose control, testosterone may also promote fat distribution favoring a healthier body composition, often associated with lower visceral fat, which is linked to metabolic dysfunction. This multifaceted approach to metabolism underscores why improved glucose control is a key benefit of testosterone replacement. Other aspects like muscle mass increase and energy levels are also notable but are not uniquely focused on metabolic parameters in the same direct manner as glucose control.